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INGs are potential drug targets for cancer

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence, apoptosis, differentiation, angiogenesis, DNA repair, metastasis, and invasion by multiple pathways. In addition, INGs increase cancer cell sensitivity for chemotherapy and radiotherapy, while clinical observations show that INGs are frequently lost in some types of cancers. The aim of the study was to summarize the recent progress regarding INGs regulating tumor progression.

Methods

The literatures of INGs regulating tumor progression were searched and assayed.

Results

The regulating signaling pathways of ING1, ING2, ING3 or ING4 on tumor progression were shown. The mechanisms of INGs on tumor suppression were also assayed.

Conclusions

This review better summarized the signaling mechanism of INGs on tumor suppression, which provides a candidate therapy strategy for cancers.

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Acknowledgments

This work was supported by Natural Science Foundation of Jiangsu Province (BK20131251) and by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

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    1. Department of Oncology, Affiliated Wujin People’s Hospital, Jiangsu University, Changzhou, 212017, People’s Republic of China

      Runyun Zhang, Jianhua Jin & Yongzhong Hou

    2. Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, People’s Republic of China

      Runyun Zhang, Juanjuan Shi & Yongzhong Hou

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    1. Runyun Zhang
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    Runyun Zhang and Jianhua Jin have contributed equally to this work.

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    Zhang, R., Jin, J., Shi, J. et al. INGs are potential drug targets for cancer. J Cancer Res Clin Oncol 143, 189–197 (2017). https://doi.org/10.1007/s00432-016-2219-z

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