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Study on mechanism of release oxygen by photo-excited hemoglobin in low-level laser therapy

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Abstract

According to the calculated results on the charge distribution of oxygenated heme and deoxygenated heme, and based on the theory of electron excitations in photo-acceptor molecules and the absorption spectra of hemoglobin, it is found that low-level laser within the waveband of about 800–1060 nm can promote the release of oxygen from oxyhemoglobin and improve the oxygen supply of capillaries to surrounding tissues. Furthermore, the reasons have been explained that why the low-level laser at a wavelength of 830 nm is better in the treatment on burn injury and stimulation of hair growth. We also explained why the near-infrared laser of 1064 nm is applied to the forehead to improve cerebral oxygenation in healthy humans. Finally, according to comparison of atomic charge distribution in heme before and after bound to small molecule of carbon monoxide or nitric oxide, it could be inferred that the low-level laser with an appropriate wavelength can promote the carbon monoxide hemoglobin and nitric oxide hemoglobin to dissociate the carbon monoxide molecules and the nitric oxide molecules. This may be used for adjuvant therapy of carbon monoxide poisoning or nitric oxide poisoning.

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Funding

This study is funded by The Ministry of Education “Chunhui Plan” (10801X10096026) and Southwest Jiaotong University “Hundred Talents Program” Funding (10801B10096015).

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Authors and Affiliations

  1. School of Physical Science and Technology, Southwest Jiaotong University, Chengdu, 610031, China

    Yanliang Xu, Yuexia Lin, Simin Gao & Junfeng Shen

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  1. Yanliang Xu
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  2. Yuexia Lin
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  3. Simin Gao
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  4. Junfeng Shen
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Correspondence to Yanliang Xu.

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The authors declare that they have no conflict of interest.

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The studies were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Xu, Y., Lin, Y., Gao, S. et al. Study on mechanism of release oxygen by photo-excited hemoglobin in low-level laser therapy. Lasers Med Sci 33, 135–139 (2018). https://doi.org/10.1007/s10103-017-2363-y

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  • DOI: https://doi.org/10.1007/s10103-017-2363-y

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