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Detection of a new species of torque teno mini virus from the gingival epithelium of patients with periodontitis

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Abstract

We describe a novel species of torque teno mini virus called TTMV-204, which was isolated from the gingival epithelium of patients with periodontitis and characterized using viral metagenomics. The sequence of the full genome is 2824 nt in length. Phylogenetic analysis and genetic analyses show classic Betatorquevirus species organization with less than 40% amino acid similarity in ORF1. The prevalence of TTMV-204 in the periodontitis patient population was 18.75% (15/80), which was higher than in periodontally healthy individuals (10.00%, 10/80). However, the difference of the TTMV-204 prevalence between two groups was not statistically significant (p = 0.115). Further investigation is required to determine whether this new virus is associated with inflammation.

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Acknowledgments

The authors appreciate the efforts of Prof. Spandole from the Department of Genetics at the University of Bucharest for providing the ORF1 sequences of the referenced strains from GenBank.

Author contributions

X.P.F and T.L.S designed the study. X.T.D and E.D completed the data analysis and statistics. Y.Z and F.L completed the sample collection and the amplifications of the newly discovered full-length human anellovirus. Y.Z, F.L, and X.C completed the epidemiological investigation. All of the authors have read and approved the final manuscript.

Funding

The study was funded by the National Natural Science Foundation of China (No. 81470737).

Author information

Author notes

  1. Yu Zhang and Fei Li these authors contributed equally to this study and share first authorship.

    Tong-Ling Shan and Xi-Ping Feng these authors contributed equally to this study and share corresponding authorship.

Authors and Affiliations

  1. Department of Preventive Dentistry, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China

    Yu Zhang, Fei Li, Xi Chen & Xi-Ping Feng

  2. Department of Swine Infectious Disease, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China

    Tong-Ling Shan

  3. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China

    Tong-Ling Shan

  4. Blood Systems Research Institute, San Francisco, CA, USA

    Xu-Tao Deng & Eric Delwart

  5. Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA

    Xu-Tao Deng & Eric Delwart

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  1. Yu Zhang
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  2. Fei Li
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  3. Xi Chen
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Correspondence to Tong-Ling Shan or Xi-Ping Feng.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Ethics Committee of the Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University approved this study (No. 201406).

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Zhang, Y., Li, F., Chen, X. et al. Detection of a new species of torque teno mini virus from the gingival epithelium of patients with periodontitis. Virus Genes 53, 823–830 (2017). https://doi.org/10.1007/s11262-017-1505-4

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