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Decreased interhemispheric coordination in the posterior default-mode network and visual regions as trait alterations in first-episode, drug-naive major depressive disorder

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Abstract

Decreased homotopic connectivity has been implicated in the neurophysiology of major depressive disorder (MDD) with inconsistent findings. A combination of clinical and methodological variabilities may account for the inconsistency, and thus limiting the reproducibility of the findings. The present study aims to examine voxel-mirrored homotopic connectivity (VMHC) alterations in two independent samples of patients with first-episode, drug-naive MDD. The samples included 59 patients and 31 controls from Sample 1 and 29 patients and 24 controls from Sample 2. VMHC was evaluated in both samples with an overlapping technique, which was used to define regions of abnormality common to both samples. Moreover, receiver operating characteristic curve and support vector machine were employed to differentiate the patients from the controls in both samples. Compared with the controls, the patients in both samples exhibited decreased VMHC in overlapped brain clusters, including the posterior cingulate cortex (PCC) and cuneus. Moreover, the VMHC values in the PCC and cuneus and a combination of the VMHC values in these two clusters could robustly discriminate between patients and controls with good sensitivities and specificities in both samples. This study is the first to examine VMHC abnormalities in first-episode, drug-naive patients with MDD in two independent samples by using an overlapped technique. The patients exhibit decreased VMHC in overlapping clusters in the posterior default-mode network and visual regions, which may be trait alterations for MDD. The present study provides a new perspective for understanding the neurophysiologic abnormalities of VMHC in MDD.

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Funding

This study was supported by grants from the National Key National Key R&D Program of China (2016YFC1307100 and 2016YFC1306900) and the National Natural Science Foundation of China (Grant Nos. 81571310, 81630033, 81771447, and 81471363).

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Authors and Affiliations

  1. Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China

    Wenbin Guo, Xilong Cui, Jindong Chen, Guangrong Xie, Renrong Wu & Jingping Zhao

  2. National Clinical Research Center on Mental Disorders, Changsha, Hunan, 410011, China

    Wenbin Guo, Xilong Cui, Jindong Chen, Guangrong Xie, Renrong Wu & Jingping Zhao

  3. National Technology Institute on Mental Disorders, Changsha, Hunan, 410011, China

    Wenbin Guo, Xilong Cui, Jindong Chen, Guangrong Xie, Renrong Wu & Jingping Zhao

  4. Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China

    Feng Liu & Huafu Chen

  5. Mental Health Center, The Second Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, 530007, China

    Zhikun Zhang

  6. Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, UT Houston Medical School, 1941 East Road, Houston, TX, 77054, USA

    Xiangyang Zhang

  7. Guangzhou Hui Ai Hospital, Affliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

    Jingping Zhao

Authors
  1. Wenbin Guo
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  2. Xilong Cui
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  3. Feng Liu
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  4. Jindong Chen
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  5. Guangrong Xie
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  6. Renrong Wu
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  7. Zhikun Zhang
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  8. Huafu Chen
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  9. Xiangyang Zhang
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  10. Jingping Zhao
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Corresponding authors

Correspondence to Wenbin Guo or Jingping Zhao.

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Conflict of interest

Author Guo W declares that he has no conflict of interest. Author Cui X declares that she has no conflict of interest. Author Liu F declares that he has no conflict of interest. Author Chen J declares that he has no conflict of interest. Author Xie G declares that he has no conflict of interest. Author Wu R declares that she has no conflict of interest. Author Zhang Z declares that she has no conflict of interest. Author Chen H declares that he has no conflict of interest. Author Zhang X declares that he has no conflict of interest. Author Zhao J declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Guo, W., Cui, X., Liu, F. et al. Decreased interhemispheric coordination in the posterior default-mode network and visual regions as trait alterations in first-episode, drug-naive major depressive disorder. Brain Imaging and Behavior 12, 1251–1258 (2018). https://doi.org/10.1007/s11682-017-9794-8

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