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Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis

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Abstract

Objective

To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases.

Methods

We surveyed studies on the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed in a fixed/random effect model.

Results

We identified 14 studies using a PubMed search. Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (A/G, 5 studies), −881 (A/G, 3 studies), −826 (C/T, 3 studies), and −297 (C/T, 3 studies). We did not detect associations of NFKBIA gene polymorphisms at positions 2758, −881, −297 with autoimmune and inflammatory diseases. An association of NFKBIA gene −826C/T polymorphism with autoimmune and inflammatory diseases was found (C vs. T: OR = 1.81, 95% CI = 0.97–3.36, P = 0.06; CT + TT vs. CC: OR = 2.11, 95% CI = 1.07–4.19, P = 0.03; TT vs. CC + CT: OR = 2.20, 95% CI = 0.78–6.21, P = 0.06; TT vs. CC: OR = 2.87, 95% CI = 0.78–10.62, P = 0.11; CT vs. CC: OR = 2.02, 95% CI = 1.22–3.36, P = 0.006).

Conclusion

This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene −826C/T polymorphism, but not with 2758A/G, −881A/G, and −279C/T.

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Acknowledgements

We thank all those who assisted with this study. We especially acknowledge the kind help of Dr. E. Leshinsky-Silver and Dr. JT Epplen. This work was supported by grants from the National Natural Science Foundation of China (30972530).

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Authors and Affiliations

  1. Department of Dermatology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, 214023, Jiangsu, China

    Guo-Long Zhang, He-Jian Shi, Xu-Feng Du & Qing Zhou

  2. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China

    Yan-Feng Zou & Xiao-Liang Feng

  3. Department of Dermatology, Wuxi People’s Hospital, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China

    Guo-Long Zhang, He-Jian Shi, Xu-Feng Du, Min-Hua Shao, Yong Gu & Qing Zhou

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  1. Guo-Long Zhang
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Correspondence to Yan-Feng Zou.

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Zhang, GL., Zou, YF., Feng, XL. et al. Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis. Inflamm. Res. 60, 11–18 (2011). https://doi.org/10.1007/s00011-010-0216-2

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  • DOI: https://doi.org/10.1007/s00011-010-0216-2

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