Abstract
Although the pathogenesis of endometriosis is not fully understood, it is often considered to be an inflammatory disease. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (e.g., interleukin-4 and -10, and transforming growth factor-β1) occurs in women with endometriosis, including in serum, peritoneal fluid and ectopic lesions. These anti-inflammatory cytokines also have indispensable roles in the progression of endometriosis, including by promoting survival, growth, invasion, differentiation, angiogenesis, and immune escape of the endometriotic lesions. In this review, we provide an overview of the expression, origin, function and regulation of anti-inflammatory cytokines in endometriosis, with brief discussion and perspectives on their future clinical implications in the diagnosis and therapy of the disease.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (NSFC) (nos. 91542108, 81471513, 31671200, 81601354, 31600735 and 81571509), the Shanghai Rising-Star Program (no. 16QA1400800), the Innovation-oriented Science and Technology Grant from NPFPC Key Laboratory of Reproduction Regulation (CX2017-2), the Program for Zhuoxue of Fudan University, the National Science Foundation of Jiangsu Province (no. BK20160128), the Fundamental Research Funds for the Central Universities (no. 021414380180), the Open Project Program of Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases (CN) (no. 14DZ2271700).
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MQL designed and wrote the review, and supervised and critically reviewed the complete manuscript. WJZ and HLY performed the literature search, drafted the manuscript and prepared the figures. JS, KKC and JM helped to perform revisions and critically discussed the completed manuscript.
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Zhou, WJ., Yang, HL., Shao, J. et al. Anti-inflammatory cytokines in endometriosis. Cell. Mol. Life Sci. 76, 2111–2132 (2019). https://doi.org/10.1007/s00018-019-03056-x
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DOI: https://doi.org/10.1007/s00018-019-03056-x