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Association of hOGG1 genotype with life style and oxidative DNA damage among Chinese ethnic populations

  • Toxicogenomics
  • Published:
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Abstract

To assess the natural variation of hOGG1 gene and the gene–environmental interactions, the hOGG1 codon 326 polymorphism and urinary 8-OHdG levels were investigated in large samples (n = 953) of healthy individuals from five Chinese ethnic populations by using PCR-RFLP and HPLC-ECD. Life-style parameters under study were obtained through a questionnaire. The allelic frequencies of the hOGG1 gene in the Chinese populations were found to be 0.16 (Ser/Ser), 0.49 (Ser/Cys) and 0.35 (Cys/Cys), respectively. The frequencies of Ser326Cys polymorphism were significantly different among the five Chinese ethnic populations (P = 0.002). No association was found between the hOGG1 gene polymorphism and other life-style parameters except for the association between Ser326Cys and smoking (P = 0.027). A significant increase of urinary 8-OHdG level was observed in Cys326Cys allelic healthy subjects (P = 0.033). These results suggest that there are natural variations of hOGG1 gene among Chinese ethnic populations. Smoking relates to Cys/Cys polymorphism frequencies, and oxidative DNA damage is repaired less in individuals with the hOGG1 Cys326Cys genotype.

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Acknowledgments

The research was supported by funds from the National Natural Science Foundation of China (30872149/C1504) and Guangdong Natural Science Foundation (8451802003000336). We are grateful to Dr. Mak Ying-Tat from the Chinese University of Hong Kong, Hong Kong, for his revision. The authors also wish to thank all subjects who volunteered to participate. We apologize to the many investigators whose research could not be cited due to space limitations.

Conflict of interest statement

The authors declare they have no competing financial interests.

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Authors and Affiliations

  1. Department of Occupational and Environmental Health, Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People’s Republic of China

    Yuebin Ke, Wenqing Lu & Tangchun Wu

  2. Department of Genetic Toxicology, Shenzhen Center for Diseases Control and Prevention, 518020, Shenzhen, People’s Republic of China

    Yuebin Ke, Youshen Jiang, Zhixiong Zhuang & Lu Li

  3. Department of Environmental Health, West China School of Public Health, Sichuan University, 610041, Chengdu, People’s Republic of China

    Zhunzhen Zhang

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  1. Yuebin Ke
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  2. Zhunzhen Zhang
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  3. Youshen Jiang
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  4. Zhixiong Zhuang
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  5. Lu Li
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  6. Wenqing Lu
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  7. Tangchun Wu
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Correspondence to Yuebin Ke or Tangchun Wu.

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Ke, Y., Zhang, Z., Jiang, Y. et al. Association of hOGG1 genotype with life style and oxidative DNA damage among Chinese ethnic populations. Arch Toxicol 83, 663–668 (2009). https://doi.org/10.1007/s00204-009-0421-3

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  • DOI: https://doi.org/10.1007/s00204-009-0421-3

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