Abstract
Background
Renal cell carcinoma (RCC) is the third most common genitourinary cancer. Activated platelets play a pivotal role in cancer development and progression. Altered mean platelet volume (MPV) has been reported in several malignancies. The aim of the present study was to investigate the association of MPV with RCC.
Study design
The study consisted of 145 patients with RCC, 110 patients with benign renal tumor and 132 healthy control subjects between January 2015 and December 2015. All participants’ clinical and laboratory characteristics at initial diagnosis were collected. The odds ratios (ORs) for RCC were calculated using multivariate logistic regression analysis after adjusting for confounding variables across MPV quartiles.
Results
The patients with RCC had decreased pre-operative MPV compared to the patients with benign renal tumor and healthy control subjects. Furthermore, pre-operative MPV was reduced in benign renal tumor compared with healthy control subjects. Surgical tumor resection resulted in a significant increase in MPV levels (8.7 fL vs. 9.0 fL; p = 0.011). After adjusting for other risk factors, the ORs (95% CIs) for RCC in each MPV quartile were 25.725 (7.556–87.585), 7.447 (2.701–20.537), 0.703 (0.245–2.019), and 1.000, respectively.
Conclusions
RCC patients have remarkably reduced MPV compared to patients with benign renal tumor and healthy control subjects. Moreover, decreased MPV was independently associated with RCC. Our results suggest that detection of MPV may be useful to assess the risk of RCC.
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References
Vogl UM, Zehetgruber H, Dominkus M et al (2006) Prognostic factors in metastatic renal cell carcinoma: metastasectomy as independent prognostic variable. Br J Cancer 95:691–698
Bambace NM, Holmes CE (2011) The platelet contribution to cancer progression. J Thromb Haemost 9:237–249
Goubran HA, Stakiw J, Radosevic M et al (2014) Platelet-cancer interactions. Semin Thromb Hemost 40:296–305
Chadha AS, Kocak-Uzel E, Das P et al (2015) Paraneoplastic thrombocytosis independently predicts poor prognosis in patients with locally advanced pancreatic cancer. Acta Oncol 54:971–978
Feng Z, Wen H, Bi R et al (2016) Thrombocytosis and hyperfibrinogenemia are predictive factors of clinical outcomes in high-grade serous ovarian cancer patients. BMC Cancer 16:43
Heng S, Benjapibal M (2014) Preoperative thrombocytosis and poor prognostic factors in endometrial cancer. Asian Pac J Cancer Prev 15:10231–10236
Josa V, Krzystanek M, Eklund AC et al (2015) Relationship of postoperative thrombocytosis and survival of patients with colorectal cancer. Int J Surg 18:1–6
Li FX, Wei LJ, Zhang H et al (2014) Significance of thrombocytosis in clinicopathologic characteristics and prognosis of gastric cancer. Asian Pac J Cancer Prev 15:6511–6517
Seretis C, Youssef H, Chapman M (2015) Hypercoagulation in colorectal cancer: what can platelet indices tell us. Platelets 26:114–118
Gasparyan AY, Ayvazyan L, Mikhailidis DP et al (2011) Mean platelet volume: a link between thrombosis and inflammation. Curr Pharm Des 17:47–58
Gu M, Zhai Z, Huang L et al (2016) Pre-treatment mean platelet volume associates with worse clinicopathologic features and prognosis of patients with invasive breast cancer. Breast Cancer 23:752–760
Kemal Y, Demirag G, Ekiz K et al (2014) Mean platelet volume could be a useful biomarker for monitoring epithelial ovarian cancer. J Obstet Gynaecol 34:515–518
Kilincalp S, Ekiz F, Basar O et al (2014) Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer. Platelets 25:592–594
Li JY, Li Y, Jiang Z et al (2014) Elevated mean platelet volume is associated with presence of colon cancer. Asian Pac J Cancer Prev 15:10501–10504
Prokopowicz G, Życzkowski M, Nowakowski K et al (2016) Basic parameters of blood count as prognostic factors for renal cell carcinoma. Biomed Res Int 8687575
Gunduz S, Mutlu H, Uysal M et al (2014) Elucidating the correlation between treatment with tyrosine kinase inhibitors and mean platelet volume in patients with metastatic renal cell cancer. Oncol Lett 8:2249–2252
Sulzbacher I, Birner P, Träxler M et al (2003) Expression of platelet-derived growth factor-alpha alpha receptor is associated with tumor progression in clear cell renal cell carcinoma. Am J Clin Pathol 120:107–112
Mizutani Y, Wada H, Yoshida O et al (2003) The significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor activity in renal cell carcinoma. Cancer 98:730–736
Qi L, Du J, Zhang Z et al (2013) Low differentiated microvascular density and low expression of platelet-derived growth factor-BB (PDGF-BB) predict distant metastasis and poor prognosis in clear cell renal cell carcinoma. BJU Int 112:E415–E423
Xu L, Tong R, Cochran DM et al (2005) Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Res 65:5711–5719
Mantovani A, Allavena P, Sica A et al (2008) Cancer-related inflammation. Nature 454:436–444
Acknowledgements
This work was supported financially by grants from the Harbin special fund for scientific and technological innovation talents (RC2016XK004068).
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The authors declare that they have no competing interests.
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Zhi-yuan Yun and Xin Zhang contributed equally to this work.
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Yun, Zy., Zhang, X., Liu, Zp. et al. Association of decreased mean platelet volume with renal cell carcinoma. Int J Clin Oncol 22, 1076–1080 (2017). https://doi.org/10.1007/s10147-017-1158-2
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DOI: https://doi.org/10.1007/s10147-017-1158-2