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A new benzophenone from Dobinea delavayi

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Chemistry of Natural Compounds Aims and scope

A new benzophenone sesquiterpene dobiniside A (1), together with two known compounds, 4′,6-dihydroxy-2,3′,4-trimethoxybenzophenone (2) and mangiferin (3), were isolated from the root of Dobinea delavayi. The structure of the new compound was determined on the basis of spectroscopic analysis, including 1D, 2D NMR, and FAB-MS techniques as well as by comparison of the spectral data with those of related compounds reported in the literature. Compounds 1–3 were screened for antitumor activity in vitro, and compound 3 was shown to possess antitumor activity with IC50 value of 7.4 × 10–5 μM for A-549.

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Acknowledgment

We thank the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences for all spectral tests.

This research was supported by National Nonprofit Institute Research Grant of CATAS (ITBB 110301; 1630052012014), Scientific Foundation of Education Department of Guangxi Zhuang Autonomous Region (No. 201106LX694, No. 201203YB181), and Financial Assistance for Excellent Talents in University of Guangxi Zhuang Autonomous Region (No. 2011102).

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Authors and Affiliations

  1. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, 571101, Haikou, P. R. China

    Zhong-Quan Cheng, Qing-Yun Ma & You-Xing Zhao

  2. Guilin Normal College, 541001, Guilin, P. R. China

    Zhong-Quan Cheng, Dan Yang & Xin-Hui Yi

  3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650204, Kunming, P. R. China

    Jun Zhou

Authors
  1. Zhong-Quan Cheng
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  2. Dan Yang
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  3. Qing-Yun Ma
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  4. Xin-Hui Yi
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  5. Jun Zhou
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  6. You-Xing Zhao
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Corresponding author

Correspondence to You-Xing Zhao.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2013, pp. 42–43.

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Cheng, ZQ., Yang, D., Ma, QY. et al. A new benzophenone from Dobinea delavayi . Chem Nat Compd 49, 46–48 (2013). https://doi.org/10.1007/s10600-013-0502-7

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  • DOI: https://doi.org/10.1007/s10600-013-0502-7

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