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A New Friedelane Triterpenoid Possessing Cytotoxicity from the Leaves and Stems OF Drypetes hainanensis

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Chemistry of Natural Compounds Aims and scope

Phytochemical studies on the EtOH extract of Drypetes hainanensis leaves and stems afforded a new friedelane-type triterpene named 4β-hydroxy-23-nor-friedel-3-one (1), along with seven known compounds: friedelin (2), diethylhexyl phthalate (3), α-amyrin (4), β-amyrin (5), lupeol (6), friedelane-3,7-dione (7) and β-sitosterol (8). Their structures were established on the basis of spectroscopic analysis and chemical evidence. The cytotoxicity of the selected compounds 1, 2, and 7 were evaluated in vitro against three human cancer cell lines (HL-60, BEL-7402, and A549). Compounds 1 and 7 showed moderate cytotoxic activity.

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Acknowledgment

The authors acknowledge the technical assistance of the Analytical and Testing Center of Hainan University. This article is supported by the National Natural Science Foundation of Hainan (Grant No. 309001) and the State key subject of Botany at Hainan University (071001).

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Authors and Affiliations

  1. Ministry of Education Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources, Hainan University, 570228, Haikou, Hainan, P. R. China

    Deli Chen, Xu Cheng, Yuwan Sun & Pinghuai Liu

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  1. Deli Chen
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  2. Xu Cheng
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  3. Yuwan Sun
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  4. Pinghuai Liu
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Correspondence to Pinghuai Liu.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2014, pp. 84–86.

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Chen, D., Cheng, X., Sun, Y. et al. A New Friedelane Triterpenoid Possessing Cytotoxicity from the Leaves and Stems OF Drypetes hainanensis . Chem Nat Compd 50, 93–96 (2014). https://doi.org/10.1007/s10600-014-0874-3

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  • DOI: https://doi.org/10.1007/s10600-014-0874-3

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