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Adsorption of bovine serum albumin onto magnetic dual-mesoporous carbon microspheres

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Abstract

Magnetic dual-mesoporous carbon microspheres were synthesized via a simple method. The effects of Fe(NO3)3·9H2O loading amount on the morphologies, structural parameters, and magnetic properties of the materials were evaluated via X-ray diffraction, N2 sorption analysis, scanning electron microscopy, transmission electron microscopy, and physical property measurements. The average magnetic nanoparticle crystal sizes of α-Fe (16.4–26.1 nm) and Fe x O y (15.9–35.4 nm) increased with increasing Fe(NO3)3·9H2O loading amount. The specific surface areas, total pore volumes, and saturation magnetization strength of the carbon microspheres could be easily adjusted by changing the amount of Fe(NO3)3·9H2O during the synthesis. Bovine serum albumin (BSA) was selected as the adsorption protein model. The adsorption capacity of BSA onto magnetic mesoporous carbons was mainly affected by the specific surface area, pore volume of the material, pH value of solution, and ionic strength. The adsorption of BSA onto carbon microspheres followed the Sips adsorption model.

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Acknowledgments

The authors acknowledge the financial support from the National Natural Science Foundation of China (21373061) and Higher Education Talents Introducing Fund of Guangdong Province (2011), the Natural Science Foundation of Guangdong Province (S2012010009416), the Foundation for Distinguished Young Talents in Higher Education of Guangdong (2012LYM_0085, 2012LYM_0086), and the Planned Project of Science and Technology of Guangdong Province(2012B020316007,2012A020602058, 2013B020310013).

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Authors and Affiliations

  1. College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Yong Tian & Xiufang Wang

  2. Hospital of South China University of Technology, Guangzhou, 510641, China

    Jie Hong

  3. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Yufang Pan & Shaohua Wang

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  1. Yong Tian
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  2. Jie Hong
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  3. Yufang Pan
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  4. Shaohua Wang
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  5. Xiufang Wang
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Correspondence to Xiufang Wang.

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Tian, Y., Hong, J., Pan, Y. et al. Adsorption of bovine serum albumin onto magnetic dual-mesoporous carbon microspheres. J Nanopart Res 16, 2730 (2014). https://doi.org/10.1007/s11051-014-2730-6

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  • DOI: https://doi.org/10.1007/s11051-014-2730-6

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