Abstract
Bioassay-guided fractionation led to the isolation of six new flavonol glycosides, floramanosides A (1), B (2), C (3), D (4), E (5), and F (6), from the flowers of Abelmouschus manihot. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI–TOF-MS, 1D- and 2D-NMR). Activity screening results showed that the compounds had 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Guo J, Shang EX, Duan JA, Tang Y, Qian D, Su S (2010) Fast and automated characterization of major constituents in rat biofluid after oral administration of Abelmoschus manihot extract using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry and MetaboLynx. Rapid Commun Mass Spectrom 24:443–453
Lai X, Liang H, Zhao Y, Wang B (2009) Simultaneous determination of seven active flavonols in the flowers of Abelmoschus manihot by HPLC. J Chromatogr Sci 47:206–210
Li C, Wang T, Zhang Y, Gao X, Li T (2010) Isolation and identification of chemical constituents of flowers of Abelmoschus manihot (L.) Medic Flos (I). Shenyang Yaoke Daxue Xuebao 27:711–714
Li C, Wang T, Zhang Y, Han L, Liu E, Gao X (2010) Isolation and identification of chemical constituents from the flowers of Abelmoschus manihot (L.) Medic (II). Shenyang Yaoke Daxue Xuebao 27:803–807
Li C, An Y, Wang T, Shang H, Gao X, Zhang Y (2011) Isolation and identification of chemical constituents from the flowers of Abelmoschus manihot (L.) Medic (III). Shenyang Yaoke Daxue Xuebao 28:520–525
An Y, Zhang Y, Li C, Qian Q, He W, Wang T (2011) Inhibitory effects of flavonoids from Abelmoschus manihot flowers on triglyceride accumulation in 3T3-L1 adipocytes. Fitoterapia 82:595–600
Matsuda H, Wang T, Managi H, Yoshikawa M (2003) Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities. Bioorg Med Chem 11:5317–5323
Matsuda H, Molikawa T, Toguchida I, Yoshikawa M (2002) Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity. Chem Pharm Bull 50:788–795
Nakamura S, Murakami T, Nakamura J, Kobayashi H, Matsuda H, Yoshikawa M (2006) Structures of new cucurbitane-type triterpenes and glycosides, karavilagenins and karavilosides, from the dried fruit of Momordica charantia L. in Sri Lanka. Chem Pharm Bull 54:1545–1550
Yoshikawa M, Nakamura S, Kato Y, Matsuhira K, Matsuda H (2007) Medicinal flowers. XIV. New acylated oleanane-type triterpene oligoglycosides with antiallergic activity from flower buds of Chinese tea plant (Camellia sinensis). Chem Pharm Bull 55:598–605
Ghanem AA, Arafa LF, El-Baz A (2010) Oxidative stress markers in patients with primary open-angle glaucoma. Curr Eye Res 35:295–301
Suzen S, Buyukbingol E (2003) Recent studies of aldose reductase enzyme inhibition for diabetic complications. Curr Med Chem 10:1329–1352
Acknowledgments
This research was supported by Program for Changjiang Scholars and Innovative Research Team in University (PCSIR IRT0973), Applied Basic and Advanced Research Program of Tianjin (10SYSYJC28900, 10ZCKFSY09300), and Important Drug Development Fund, Ministry of Science and Technology of China (2012ZX09103201-031).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zhang, Y., He, W., Li, C. et al. Antioxidative flavonol glycosides from the flowers of Abelmouschus manihot . J Nat Med 67, 78–85 (2013). https://doi.org/10.1007/s11418-012-0651-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11418-012-0651-1