A facilely synthesized amino-functionalized metal–organic framework for highly specific and efficient enrichment of glycopeptides

Yi-Wei Zhang; Ze Li; Qiang Zhao; Ying-Lin Zhou; Hu-Wei Liu; Xin-Xiang Zhang

doi:10.1039/C4CC05179C

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A facilely synthesized amino-functionalized metal–organic framework for highly specific and efficient enrichment of glycopeptides†

Yi-Wei Zhang,^a Ze Li,^a Qiang Zhao,^a Ying-Lin Zhou,^a Hu-Wei Liu^a and Xin-Xiang Zhang*^a

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* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China
E-mail: zxx@pku.edu.cn
Fax: +86-10-62754112
Tel: +86-10-62754112

Abstract

A facilely synthesized amino-functionalized metal–organic framework (MOF) MIL-101(Cr)-NH₂ was first applied for highly specific glycopeptide enrichment based on the hydrophilic interactions. With the special characteristics of the MOF, the material performed well in selectivity and sensitivity for both standard glycoprotein samples and complex biological samples.

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DOI: https://doi.org/10.1039/C4CC05179C
Article type: Communication
Submitted: 05 Jul 2014
Accepted: 05 Aug 2014
First published: 05 Aug 2014

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Chem. Commun., 2014,50, 11504-11506

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A facilely synthesized amino-functionalized metal–organic framework for highly specific and efficient enrichment of glycopeptides

Y. Zhang, Z. Li, Q. Zhao, Y. Zhou, H. Liu and X. Zhang, Chem. Commun., 2014, 50, 11504 DOI: 10.1039/C4CC05179C

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Chemical Communications

A facilely synthesized amino-functionalized metal–organic framework for highly specific and efficient enrichment of glycopeptides†

Abstract

Supplementary files

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A facilely synthesized amino-functionalized metal–organic framework for highly specific and efficient enrichment of glycopeptides

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