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A Novel Coordinated Polymer [Cu(En)2][(PzTp)Fe(CN)3]2: Synthesis, Crystal Structure, and Inhibiting Left Atrial Myxoma Cell Activity in vitro

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Abstract

A new cyanide-bridged neutral centrosymmetric cluster [Cu(En)2][(PzTp)Fe(CN)3]2 (I), where En = ethylenediamine, PzTp = tetra(pyrazol-1-yl)borate) was synthesized by a programmed self-assembly of preformed building blocks. Characterization with single crystal X-ray diffraction (CIF file CCDC no. 1555334) showed that the Cu2+ center was located in a large distorted octahedral environment due to the obvious Jahn–Teller effect, which was demonstrated by continuous shape measures with the SHAPE program. Furthermore, no coordinated or free solvent molecules existed in the clusters, showing good roomtemperature stability. In addition, in vitro anticancer activity of compound I on three human cancer cells (SKOV3, A2780, and OVCAR) was further determined.

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Authors and Affiliations

  1. Department of Cardiology, Wenzhou City Hospital of Traditional Chinese Medicine and Western Medicine Combined, Wenzhou, Zhejiang, P.R. China

    X. L. Zhou, D. K. Chen & F. He

  2. Department of Cardiology, Shenzhen University General Hospital, Shenzhen, Guangdong, P.R. China

    F. Q. Dong

  3. Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China

    C. L. Hong

Authors
  1. X. L. Zhou
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  2. F. Q. Dong
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  3. C. L. Hong
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  4. D. K. Chen
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  5. F. He
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Correspondence to F. He.

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Zhou, X.L., Dong, F.Q., Hong, C.L. et al. A Novel Coordinated Polymer [Cu(En)2][(PzTp)Fe(CN)3]2: Synthesis, Crystal Structure, and Inhibiting Left Atrial Myxoma Cell Activity in vitro. Russ J Coord Chem 44, 179–182 (2018). https://doi.org/10.1134/S1070328418030089

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  • DOI: https://doi.org/10.1134/S1070328418030089

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