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A novel catalytic application of heteropolyacids: chemical transformation of major ginsenosides into rare ginsenosides exemplified by Rg1

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Abstract

High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was developed for analyzing the hydrolytic mixtures of ginsenoside Rg1 in acidic conditions (pH 3). Three catalysts, a heteropolyacid (H4SiW12O40, SiW12 for short), its complex with γ-CD (SiW12/γ-CD for short) and formic acid, were used for comparison. The chemical transformation products were identified based on the accurate mass measurement and the fragment ions obtained from tandem mass spectrometry. It was concluded that the catalytic efficiency of SiW12 (≈SiW12/γ-CD) is ca. 410 times higher than that of formic acid, thus becoming the most efficient catalyst for chemical transformations of ginsenosides.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (21371025), the 111 Project (B07012) and the degree and postgraduate education development research project (YJYJG2015B07) by Beijing Institute of Technology.

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Authors and Affiliations

  1. Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Institute of Technology, Beijing, 100081, China

    Jie Cao, Chang Liu, Qianqian Wang & Yuze Li

  2. Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Beijing Institute of Technology, Beijing, 100081, China

    Jie Cao, Chang Liu, Qianqian Wang & Yuze Li

  3. School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China

    Jie Cao, Chang Liu, Qianqian Wang & Yuze Li

  4. Agilent Technologies Co., Ltd., Beijing, 100102, China

    Qing Yu

Authors
  1. Jie Cao
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  2. Chang Liu
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  3. Qianqian Wang
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  4. Yuze Li
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  5. Qing Yu
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Correspondence to Jie Cao.

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11426_2016_439_MOESM1_ESM.doc

A Novel Catalytic Application of Heteropolyacids: Chemical Transformation of Major Ginsenosides into Rare Ginsenosides Exemplified by Rg1

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Cao, J., Liu, C., Wang, Q. et al. A novel catalytic application of heteropolyacids: chemical transformation of major ginsenosides into rare ginsenosides exemplified by Rg1 . Sci. China Chem. 60, 748–753 (2017). https://doi.org/10.1007/s11426-016-0439-6

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  • DOI: https://doi.org/10.1007/s11426-016-0439-6

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